Purpose

This study will evaluate the safety, tolerability, DLTs, MTD, and preliminary anti tumor activity of tivozanib in combination with durvalumab in subjects with advanced HCC.

Condition

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  1. ≥ 18 years old
  2. Signed and dated written informed consent
  3. Untreated histologically or cytologically confirmed unresectable locally advanced or metastatic hepatocellular carcinoma. Measurable or evaluable disease by RECIST 1.1 criteria.
  4. Child-Pugh Class A.
  5. ECOG performance status ≤ 1 and life expectancy ≥ 3 months.
  6. Body weight > 30 kg
  7. Measured creatinine clearance (crCL) >40 mL/min or calculated crCL >40 mL/min as determined by Cockcroft-Gault (using actual body weight) Males CrCL = Weight (kg) × (140 - Age) 72 × serum creatinine (mg/dL) Females CrCL = Weight (kg) × (140 - Age) 85 × serum creatinine (mg/dL)
  8. Sexually active pre-menopausal female subjects (and female partners of male subjects) must use highly effective contraceptive measures, while on study and for at least 90 days after the last dose of study drug. Sexually active male subjects must use adequate contraceptive measures, while on study and for at least 90 days after the last dose of study drug. All fertile male and female subjects and their partners must agree to use a highly effective method of contraception.

Exclusion Criteria

  1. Subjects who have received prior systemic treatment for HCC
  2. Female subjects who are pregnant or breastfeeding or male or female subjects of reproductive potential who are not willing to employ effective birth control from screening to 90 days after the last dose of study drug.
  3. Brain metastases or spinal cord compression. Subjects with suspected brain metastases at screening should have an MRI (preferred) or CT scan each preferable with IV contrast of the brain prior to study entry. Brain metastases will not be recorded on RECIST Target Lesions at baseline.
  4. Any of the following hematologic abnormalities:
  5. Hemoglobin < 9.0 g/dL
  6. Absolute neutrophil count (ANC) < 1500 per mm3
  7. Platelet count < 75,000 per mm3
  8. Any of the following serum chemistry or urinalysis abnormalities:
  9. Total bilirubin > 2 × ULN (>2.5 mg/dL in subjects with Gilbert's syndrome)
  10. AST or ALT > 5 × ULN
  11. Alkaline phosphatase > 2.5 × ULN (or > 5 × ULN for subjects with liver or bone metastasis)
  12. Serum creatinine > 1.5 × ULN
  13. > 2+ proteinuria
  14. History of hepatic encephalopathy within past 12 months or requirement for medications to prevent or control encephalopathy (eg, no lactulose, rifaximin, etc if used for purposes of hepatic encephalopathy).
  15. GI Bleeding (eg, esophageal varices or ulcer bleeding) within 12 months. (Note: For patients with a history of GI bleeding for more than 12 months or assessed as high risk for esophageal variceal bleed by the Investigator, adequate endoscopic therapy according to institutional standards is required).
  16. Clinically meaningful ascites defined as ascites requiring non-pharmacologic intervention (eg, paracentesis) to maintain symptomatic control, within 6 months prior to the first scheduled dose. Subjects on stable doses of diuretics for ascites for ≥ 2 months are eligible.
  17. Main portal vein thrombosis (Vp4) as documented on imaging. (VP4 is defined as portal vein thrombosis in the main trunk of the portal vein or a portal vein branch contralateral to the primarily involved lobe (or both).
  18. For subjects who require ongoing therapeutic anti-coagulation or anti-platelet therapy; the subject must be off either therapy for at least 7 days prior to the first dose of investigational product. Low-dose aspirin for cardiac prophylaxis/protection is permitted per local institutional standards.
  19. Patients co-infected with HBV and HCV. HBV positive [presence of hepatitis B surface antigen (HBsAg) and/or hepatitis B core antibodies (anti-HBcAb) with detectable HBV DNA (≥10IU/ml)]; HCV positive (presence of anti-HCV antibodies).
  20. Major surgery (as defined by the investigator) within 28 days prior to first dose of IP or still recovering from prior surgery. Local procedures (eg, core needle biopsy, and prostate biopsy) are allowed if completed at least 3 days prior to the administration of the first dose of study treatment.
  21. Significant cardiovascular disease, including:
  22. Clinically symptomatic heart failure. Subjects with a history of heart failure must have an ECHO or MUGA scan to document left ventricular ejection fraction (LVEF) > 45% prior to start of protocol therapy
  23. Any New York Heart Association classification ≥ Class 2 (prefer Class 0 or 1)
  24. Any stenting procedure within the last 3 months
  25. Venous thromboembolism or arterial thromboembolism within the last 3 months
  26. Any IVC tumor thrombosis
  27. History of a hemorrhagic event (i.e., GI bleed within 6 months)
  28. Uncontrolled hypertension: blood pressure >150/95 mmHg on more than 2 antihypertensive medications, on two consecutive measurements obtained at least 24 hours apart. Subjects with a history of hypertension must have been on stable doses of anti-hypertensive drugs for ≥ 2 weeks prior to start of protocol therapy.
  29. Myocardial infarction within 3 months prior to start of protocol therapy
  30. Subjects with delayed healing of wounds, ulcers, and/or bone fractures
  31. Serious/active infection or infection requiring parenteral antibiotics
  32. Inadequate recovery from any prior surgical procedure; major surgical procedure within 4 weeks prior to start of protocol therapy.
  33. Inability to comply with protocol requirements
  34. History of another primary malignancy except for:
  35. Malignancy treated with curative intent and with no known active disease ≥ 5 years before the first dose of study drug and low potential risk for recurrence
  36. Adequately treated non-melanoma skin cancer of lentigo maligna without evidence of disease
  37. Active infection including tuberculosis (clinical evaluation that includes clinical history, physical examination and radiographic findings, and tuberculosis testing in line with local practice), , hepatitis C, or human immunodeficiency virus (positive HIV 1/2 antibodies). Subjects positive for hepatitis C (HCV) antibody are eligible only if polymerase chain reaction is negative for HCV RNA.
  38. Patients with a history or current HBV infection (detectable HBV DNA), should be placed on anti-viral treatment and tested at every cycle for HBV DNA viral load.
  39. Treatment with systemic hormonal therapy within 3 weeks prior to start of protocol therapy, with the exception of:
  40. Hormonal therapy for appetite stimulation or contraception
  41. Nasal, ophthalmic, inhaled and topical steroid preparations
  42. Oral replacement therapy for adrenal insufficiency
  43. Low-dose maintenance steroid therapy (equivalent of prednisone 10mg/day) for other conditions
  44. Hormone replacement therapy such as testosterone
  45. Strong CYP3A4 inducers within 2 weeks prior to start of, or during, protocol therapy.
  46. Prior exposure to tivozanib or any checkpoint inhibitor
  47. History of allogeneic organ transplantation
  48. Active or prior documented autoimmune or inflammatory disorders (including inflammatory bowel disease [e.g., colitis or Crohn's disease], diverticulitis [with the exception of diverticulosis], systemic lupus erythematosus, Sarcoidosis syndrome, or Wegener syndrome [granulomatosis with polyangiitis, Graves' disease, rheumatoid arthritis, hypophysitis, uveitis, etc.]). The following are exceptions to this criterion:
  49. Subjects with vitiligo or alopecia
  50. Subjects with hypothyroidism (e.g., following Hashimoto syndrome) stable on hormone replacement
  51. Any chronic skin condition that does not require systemic therapy
  52. Subjects without active disease in the last 5 years may be included but only after consultation with Medical Monitor
  53. Subjects with celiac disease controlled by diet alone
  54. Uncontrolled intercurrent illness, including but not limited to, ongoing or active infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable angina pectoris, uncontrolled cardiac arrhythmia, active interstitial lung disease, serious chronic gastrointestinal conditions associated with diarrhea, or psychiatric illness/social situations that would limit compliance with study requirement, substantially increase risk of incurring AEs or compromise the ability of the subject to give written informed consent
  55. History of leptomeningeal carcinomatosis
  56. History of active primary immunodeficiency
  57. Mean QT interval corrected for heart rate using Fridericia's formula (QTcF) ≥470 ms calculated from 3 ECGs (within 15 minutes at 5 minutes apart
  58. Known allergy or hypersensitivity to any of the study drugs or any of the study drug excipients
  59. Concurrent enrolment in another clinical study, unless it is an observational (non interventional) clinical study or during the follow-up period of an interventional study
  60. Receipt of live attenuated vaccine within 30 days prior to the first dose of study drug. Note: Subjects, if enrolled, should not receive live vaccine whilst receiving study drug and up to 30 days after the last dose of study drug.
  61. Current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab. The following are exceptions to this criterion:
  62. Intranasal, inhaled, topical steroids, or local steroid injections (e.g., intra articular injection)
  63. Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or its equivalent
  64. Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication)
  65. Previous study drug assignment in the present study

Study Design

Phase
Phase 1/Phase 2
Study Type
Interventional
Intervention Model
Sequential Assignment
Intervention Model Description
Phase 1 followed by expansion cohort
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Tivozanib in Combination with Durvalumab
Tivozanib in Combination with Durvalumab
  • Drug: Tivozanib
    Dose level 1: 1.0mg for 21 days followed by 7 days rest; Dose level -1: 1.0mg every other day
    Other names:
    • Fotivda
  • Drug: Durvalumab
    1500mg every 28 days
    Other names:
    • Imfinzi

Recruiting Locations

Montefiore Medical Center
Bronx, New York 10467

More Details

Status
Recruiting
Sponsor
AVEO Pharmaceuticals, Inc.

Study Contact

Chief Medical Officer
6175881960
Clinical@aveooncology.com

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.