Study of Acarbose in Longevity
The investigators are studying the effects of acarbose on muscle and adipose gene transcription in older adults.
- Eligible Ages
- Between 60 Years and 100 Years
- Eligible Genders
- Accepts Healthy Volunteers
- age >60 years
- impaired fasting glucose (IFG) or impaired glucose tolerance (IGT)
- heart failure
- inflammatory conditions
- active liver disease
- poorly controlled hypertension
- recent cardiovascular disease event (last 6 months)
- inflammatory bowel disease
- history of bariatric or other gastric surgery
- cigarette smoking
- serious substance abuse.
- Treatment with drugs known to influence glucose metabolism
- Hypersensitivity to acarbose or any component of the formulation.
- Treatment with anti-coagulant medications or anti-platelet drugs
- Phase 2
- Study Type
- Intervention Model
- Crossover Assignment
- Primary Purpose
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
|Participants will take acarbose three times daily for 10 weeks (titration over 4 weeks, maintenance 6 weeks). After a two week washout, participants will take placebo three times daily for a total of 10 weeks (titration over 4 weeks, maintenance 6 weeks).||
|Participants will take placebo three times daily for 10 weeks (titration over 4 weeks, maintenance 6 weeks). After a two week washout, participants will take acarbose three times daily for a total of 10 weeks (titration over 4 weeks, maintenance 6 weeks).||
- NCT ID
- Montefiore Medical Center
Study ContactErika F Brutsaert, MD
Acarbose, an FDA approved drug for the treatment of type 2 diabetes, has known effects on glucose metabolism. Evidence from mice indicates that acarbose may prolong lifespan. In humans, acarbose improves inflammatory markers and reduces cardiovascular events. Consequently, acarbose is of interest in clinical translational aging research since it may influence fundamental processes that contribute to age-related diseases. The study described herein is an exploratory study to examine the effect of acarbose treatment on the biology of aging in humans. Specifically, the investigators plan to study whether treatment with a 10 week course of acarbose will alter the gene expression profile in adipose tissue and muscle in older adults in pathways that are known to be affected by human aging, in a placebo-controlled crossover study.