Biomarkers, Neurodevelopment and Preterm Infants
Purpose
Approximately 2% of neonates in the US are born very preterm. Preterm births are associated with impaired cognitive, language and motor function, and increased risk for autism spectrum disorders. Epidemiological studies indicate a dose-response relationship between gestational age at delivery and cognitive impairments, with the most immature of newborns being the most susceptible to developmental delays. Sensitive and reproducible biomarkers of long-term neurocognitive impairments are currently lacking. The investigators seek to identify epigenetic markers that mediate the relationship between adverse prematurity-related exposures and neurocognitive impairments. The overarching hypothesis of this proposal is that DNA methylation profiles of CD34+ hematopoetic progenitor and stem cells from very preterm infants can be used as a risk-stratifying biomarker for predicting neurocognitive impairment in childhood.
Conditions
- Preterm
- Neurodevelopmental Disorder
- Epigenetic Changes
Eligibility
- Eligible Ages
- Between 1 Day and 2 Days
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- <32 weeks" gestation - Born at Weiler Division of Montefiore
Exclusion Criteria
- Intraventricular hemorrhage - Chromosomal abnormalities - Congenital viral conditions
Study Design
- Phase
- Study Type
- Observational [Patient Registry]
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Group 1 | Preterm infants <32 weeks gestational age |
|
More Details
- Status
- Terminated
- Sponsor
- Montefiore Medical Center