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Purpose

This research study is collecting and storing samples of bone marrow and blood from patients with relapsed acute lymphoblastic leukemia or relapsed non-Hodgkin lymphoma. Collecting and storing samples of bone marrow and blood from patients with cancer to study in the laboratory may help doctors learn more about cancer and help predict the recurrence of cancer.

Conditions

Eligibility

Eligible Ages
Under 30 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Criteria


Inclusion Criteria:

- Diagnosis of acute lymphoblastic leukemia (ALL) or prior history of non-Hodgkin
lymphoma

- In first or subsequent marrow relapse with ≥ 25% blasts in bone marrow and/or
peripheral blood

- Bone marrow and/or peripheral blood samples (≥ 5 mL) required at the time of diagnosis
of relapse

- No concurrent systemic antileukemic treatment administered for current relapse

- Intrathecal chemotherapy allowed

- On-therapy relapse allowed

Study Design

Phase
Study Type
Observational
Observational Model
Case-Only
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
Ancillary-Correlative (Collecting and banking ALL specimens) Patients undergo collection of bone marrow and peripheral blood at diagnosis of relapse and/or at the end of the first month of treatment.
  • Other: Cytology Specimen Collection Procedure
    Correlative studies
    Other names:
    • Cytologic Sampling
  • Other: Laboratory Biomarker Analysis
    Correlative studies

More Details

Status
Completed
Sponsor
Children's Oncology Group

Study Contact

Detailed Description

OBJECTIVES: I. Establish a mechanism to bank specimens of tumor cells and host germline DNA from patients with acute lymphoblastic leukemia (ALL) at first and subsequent relapse. II. Make these specimens available to qualified researchers to study the biology of ALL. OUTLINE: This is a multicenter study. Patients undergo collection of bone marrow and peripheral blood at diagnosis of relapse and/or at the end of the first month of treatment. Patients are followed periodically for up to 10 years.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.