A Study of DF6002 Alone and in Combination With Nivolumab
Purpose
The purpose of this study is to evaluate the safety, tolerability, drug-levels, drug-effects and preliminary anti-tumor activity of DF6002 alone and in combination with Nivolumab in participants with advanced solid tumors.
Condition
- Solid Tumors
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Advanced/metastatic solid tumors, for which no standard therapy exists or standard therapy has failed among the following tumor types: melanoma, non-small cell lung cancer, small cell lung cancer, head and neck squamous cell, urothelial, gastric, esophageal, cervical, hepatocellular, merkel cell, cutaneous squamous cell carcinoma, renal cell, endometrial, triple-negative breast, ovarian, and prostate - ECOG performance status of 0 or 1 - Clinical or radiological evidence of disease - Adequate hematological, hepatic and renal function - Anticoagulants are required for the following: Khorana Risk Score ≥ 2 or as assessed by Investigator as being at high risk for venous thromboembolism (VTE) or history of VTE ≥ 6 months from enrollment
Exclusion Criteria
- Concurrent anticancer treatment (with the exception of palliative bone directed radiotherapy), immune therapy, or cytokine therapy (except for erythropoietin), major surgery (excluding prior diagnostic biopsy), concurrent systemic therapy with steroids or other immunosuppressive agents, or use of any investigational drug within 28 days before the start of study treatment - Prior treatment with DF6002, recombinant human interleukin-12 (rhIL-12)-directed therapy, or any drug containing an interleukin-12 (IL-12) moiety - Previous malignant disease other than the current target malignancy within the last 3 years, with the exception of basal or squamous cell carcinoma of the skin, localized prostate cancer or cervical carcinoma in situ - Rapidly progressive disease - Serious cardiac illness or medical conditions - Known diagnosis of antiphospholipid syndrome or clinically significant hereditary thrombophilia Other protocol-defined inclusion/exclusion criteria apply
Study Design
- Phase
- Phase 1
- Study Type
- Interventional
- Allocation
- Non-Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Dose Escalation / Monotherapy / Subcutaneously or Intravenously |
Subcutaneous portion of the study is complete. Dosing DF6002 Q4W |
|
|
Experimental Dose Escalation / Combination / Subcutaneously or Intravenously |
Subcutaneous portion of the study is complete. Dosing DF6002 Q4W Dosing nivolumab Q4W |
|
|
Experimental Safety/PK/PD / Monotherapy / Subcutaneously or Intravenously |
Subcutaneous portion of the study is complete. Dosing DF6002 Q4W |
|
|
Experimental Safety/PK/PD / Combination / Subcutaneously or Intravenously |
Subcutaneous portion of the study is complete. Dosing DF6002 Q4W Dosing nivolumab Q4W |
|
|
Experimental Efficacy Expansion / Combination / Subcutaneously or Intravenously / Melanoma |
Subcutaneous portion of the study is complete. 2L+ melanoma Dosing DF6002 Q4W Dosing nivolumab Q4W |
|
|
Experimental Efficacy Expansion / Combination / Subcutaneously or Intravenously / Non-Melanoma |
Subcutaneous portion of the study is complete. 2L+ non-melanoma skin cancer (including cSCC, BCC, and MCC) Dosing DF6002 Q4W Dosing nivolumab Q4W |
|
Recruiting Locations
Montefiore Medical Center
The Bronx 5110266, New York 5128638 10467
The Bronx 5110266, New York 5128638 10467
Contact:
Jinyu Lu, MD
Jinyu Lu, MD
More Details
- Status
- Recruiting
- Sponsor
- Dragonfly Therapeutics
Detailed Description
Assess the safety and tolerability of subcutaneous (SC) and intravenous (IV) administration of DF6002, as monotherapy and in combination with nivolumab, and to determine the maximum tolerated dose (MTD) and recommended efficacy expansion dose (REED) of SC and IV DF6002, both as monotherapy and in combination with nivolumab, for patients with advanced (unresectable, recurrent, or metastatic) solid tumors.