Early Childhood Obesity Programming by Intrauterine Growth Restriction
Purpose
The molecular mechanisms underlying developmental programming of childhood obesity remain poorly understood. Here, the investigators address major questions about early childhood obesity programming by studying CD3+ T-cells from intrauterine growth restricted (IUGR) newborns who have an increased risk for obesity and other metabolic disorders in adult life.
Conditions
- Childhood Obesity
- Epigenetics
Eligibility
- Eligible Ages
- Between 1 Hour and 24 Months
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Healthy singleton term intrauterine growth restricted (IUGR) and appropriate for gestational age (AGA) infants whose mothers are followed by the Obstetric Department of Montefiore Medical Center and who deliver at the Weiler Division of Montefiore Medical Center. Infants will be classified as IUGR if birth weight is <10th percentile for gestational age and gender based on World Health Organization (WHO) growth curves. Infants will be classified as AGA if birth weight percentile is >10th and <90th percentile - Reproductive age women, healthy enough to achieve pregnancy - Deliver a single healthy live term infant at ≥37 weeks' gestational age (GA) - All patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
Exclusion Criteria
- Multiple gestation - Maternal depression - Maternal renal disease - History of maternal smoking in the 2nd and 3rd trimester of pregnancy - Maternal gestational diabetes / Type 2 Diabetes (T2D) - Preterm birth (less than 37 weeks' gestation) - Known chromosomal or congenital anomaly - Infants in extremis - Low Apgar scores (Apgar score <7 at 5 minutes of age) - Known congenital bacterial or non-bacterial infections - Known inborn errors of metabolism
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| IUGR infants | Intrauterine growth restricted infants will be enrolled. There are no interventions. | |
| AGA infants | Appropriate for gestational age infants will be enrolled. There are no interventions. |
Recruiting Locations
The Bronx 5110266, New York 5128638 10461
More Details
- Status
- Recruiting
- Sponsor
- Montefiore Medical Center
Detailed Description
Epidemiological studies of multiple cohorts suggest an increased risk for obesity, cardiovascular disease-related death and type 2 diabetes in low birth weight infants. However, the molecular mechanisms underlying developmental programming of childhood obesity remain poorly understood. Alterations in DNA methylation during fetal life have been proposed to be one of the mechanisms that regulate this phenotype. Here, the investigators address major questions about early childhood obesity programming by studying purified subpopulations of CD3+ T-cells from intrauterine growth restricted (IUGR) newborns who have an increased risk for obesity and other metabolic disorders in adult life. The investigators will correlate altered CD3+ T-cell DNA methylation profiles in cord and peripheral blood samples and functional changes in CD3+ T-cells with adiposity in childhood.